ZNF417 and IGFBP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZNF417	IGFBP6
Description		zinc finger protein 417	insulin like growth factor binding protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Golgi Apparatus Insulin-like Growth Factor Binary Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Generic Transcription Pathway	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Depression in smokers ( 30219690)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Interacting Genes		169 interacting genes: - ADAMTSL4 AXIN2 BEGAIN BEND5 BEX3 BHLHB9 BICD2 C4orf17 CARD9 CBY2 CCDC125 CCDC136 CCDC57 CCDC85B CCNDBP1 CDR2 CDR2L CEP44 CEP70 CEP72 CEP85L CHRDL2 COG6 CSRNP1 CYSRT1 DEF8 DVL3 EFS EZHIP FAM221A FHL2 FHL3 FHL5 FRS3 FSD2 FXR1 GOLGA2 GOLGA6L9 HMBOX1 HOMEZ HOOK2 HOXA1 HSF2BP IGFBP6 IHO1 IKZF1 INKA1 JADE2 JRK KAT5 KATNBL1 KCTD7 KIF9 KIFC3 KLC3 KRT15 KRT31 KRT35 KRT38 KRT39 KRT40 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-9 KXD1 LHX3 LIMS1 LMO1 LURAP1 LZTS1 LZTS2 MAGEA8 MAST2 MCC MCCD1 MDFI MEIS3 MEOX2 MID2 MIIP MRFAP1L1 MTUS2 MYF5 MYLIP NAB2 NBPF19 NDEL1 NDUFB7 NINL NKAPL NKX3-1 NOTCH2NLA OIP5 PHC2 PICK1 PIH1D2 PLSCR1 PNMA2 PRICKLE4 PRPF31 RCN3 REL RHOQ RNF187 RORB RPGRIP1 RUNDC3A SH2B2 SMARCD1 SMYD5 SPRED1 SPRED2 SPRY1 SPRY2 SSX2IP STX11 SUV39H1 TADA2A TCF4 TEKT4 TFIP11 TLE5 TMCC2 TNS2 TRAF1 TRAF2 TRIB3 TRIM23 TRIM27 TRIM36 TRIM37 TRIM41 TRIM54 TSC1 TSGA10 TXNDC11 U2AF1 USHBP1 VPS16 VPS52 VWC2 ZBTB1 ZBTB10 ZBTB43 ZBTB8A ZBTB9 ZNF165 ZNF19 ZNF20 ZNF547 ZNF572 ZNF587 ZNF69 ZNF71 ZNF768 ZNF774 ZNF837 ZNF85 ZRANB1	40 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DDX10 EFEMP1 EFEMP2 ENKD1 EPDR1 ERBB3 GAS8 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		147687	3489
HPRD ID		18341	00902
Ensembl ID		ENSG00000173480	ENSG00000167779
Uniprot IDs		M0R230 Q8TAU3	P24592
PDB IDs			1RMJ
Enriched GO Terms of Interacting Partners?
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