KRT25 and PPL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KRT25	PPL
Description		keratin 25	periplakin
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Extracellular Exosome	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome
	Molecular Function	Molecular_function Structural Molecule Activity Protein Binding Protein Heterodimerization Activity	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Cytoskeleton Organization Aging Hair Follicle Morphogenesis Hair Cycle Intermediate Filament Organization	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization
Pathways		Keratinization Formation of the cornified envelope	Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Asthma ( 31959851 30929738) Cognitive decline rate in late mild cognitive impairment ( 26252872)	Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		22 interacting genes: HGS KRT1 KRT2 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT74 KRT75 KRT76 KRT78 KRT79 KRT8 KRT83 KRT85 KRT86 MORN4 PPL	45 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 LARP1 MRPL28 OPRM1 PBX4 PICK1 PKD1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		147183	5493
HPRD ID		17242	04187
Ensembl ID		ENSG00000204897	ENSG00000118898
Uniprot IDs		Q6ZPD6 Q7Z3Z0	O60437
PDB IDs			4Q28
Enriched GO Terms of Interacting Partners?
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