RDH12 and ADCY2

		RDH12	ADCY2
Description		retinol dehydrogenase 12	adenylate cyclase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Endoplasmic Reticulum Membrane Photoreceptor Inner Segment Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Membrane Raft
	Molecular Function	NAD-retinol Dehydrogenase Activity Protein Binding NADP-retinol Dehydrogenase Activity 11-cis-retinol Dehydrogenase Activity	Magnesium Ion Binding Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Manganese Ion Binding
	Biological Process	Retinoid Metabolic Process Visual Perception Retinol Metabolic Process Photoreceptor Cell Maintenance Cellular Detoxification Of Aldehyde	CAMP Biosynthetic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway CAMP-mediated Signaling Cellular Response To Forskolin
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Vitamin A	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
Diseases
GWAS			Anxiety and stress-related disorders ( 31116379) Atorvastatin-induced myopathy ( 31220337) Bipolar disorder ( 24618891 31043756) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Bipolar I disorder ( 31043756) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Capecitabine sensitivity ( 22864933) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Food addiction ( 27106561) LDL cholesterol levels in HIV infection ( 33109212) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Oropharynx cancer ( 27749845) Pars opercularis volume ( 31530798) Plasma factor VII activating protease levels ( 30070759) Posterior-cingulate cortex volume ( 31530798) Smoking status (heavy vs never) ( 26423011) Visceral fat ( 22589738)
Interacting Genes		6 interacting genes: ADCY2 ANXA8L1 BUB1 MAP1LC3A PLEKHA7 RBPMS	14 interacting genes: ADCY1 ADCY5 AHRR CDH18 DRD4 F2RL1 GCDH GNAS GNG2 ISL1 NUF2 OBP2A RDH12 SLC9A3
Entrez ID		145226	108
HPRD ID		10585	00052
Ensembl ID		ENSG00000139988	ENSG00000078295
Uniprot IDs		A0A0S2Z613 Q96NR8	Q08462 Q71UM8
PDB IDs
Enriched GO Terms of Interacting Partners?
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