CSH1 and PRLR

Number of citations of the paper that reports this interaction (PubMedID 10966654)
18

Data Source:
HPRD (in vitro)

		CSH1	PRLR
Description		chorionic somatomammotropin hormone 1	prolactin receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endosome Lumen Vesicle	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Endosome Lumen Receptor Complex
	Molecular Function	Growth Hormone Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding	Cytokine Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Prolactin Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Peptide Hormone Binding Cytokine Binding Metal Ion Binding
	Biological Process	Response To Nutrient Levels Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Growth Hormone Receptor Signaling Pathway	Steroid Biosynthetic Process Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Embryo Implantation Lactation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Prolactin Signaling Pathway Oncostatin-M-mediated Signaling Pathway Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Leukemia Inhibitory Factor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling	Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin
Diseases
GWAS		Height ( 25429064 23563607 31562340)	Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) Metabolite levels ( 23823483) Paneth cell defects in Crohn's disease ( 28352666) Psychotic experience ( 31553412) Response to lurasidone in schizophrenia ( 29730043)
Interacting Genes		7 interacting genes: PRLR PSMD9 PTPN12 SGTB SMAD2 SMAD4 SMAD9	22 interacting genes: CISH CREBBP CSH1 FBXW11 GH1 ICAM3 INSIG2 JAK2 MFGE8 NEK3 PLPP6 PPIA PRL PTPN11 SOCS2 SOCS3 TEC VAV1 VAV2 YWHAG YWHAZ ZAP70
Entrez ID		1442	5618
HPRD ID		08350	01457
Ensembl ID		ENSG00000136488	ENSG00000113494
Uniprot IDs		A8K6C2 P0DML2 P0DML3	P16471
PDB IDs		1Z7C	1BP3 2LFG 2N7I 3D48 3MZG 3N06 3N0P 3NCB 3NCC 3NCE 3NCF 4I18
Enriched GO Terms of Interacting Partners?
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