CRP and GP6

Number of citations of the paper that reports this interaction (PubMedID 11027634)
11

Data Source:
HPRD (in vitro)

		CRP	GP6
Description		C-reactive protein	glycoprotein VI platelet
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Raft Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium	Enzyme Linked Receptor Protein Signaling Pathway Platelet Activation Collagen-activated Signaling Pathway Positive Regulation Of Platelet Aggregation
Pathways		Classical antibody-mediated complement activation	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases
GWAS		Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 33227023 24763700 29403010 33339817 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)	Blood protein levels ( 30072576 28240269) Breast cancer and/or colorectal cancer ( 29698419) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Platelet aggregation ( 20526338 29185836) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Venous thromboembolism ( 31420334)
Interacting Genes		22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A	7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1
Entrez ID		1401	51206
HPRD ID		00422	10406
Ensembl ID		ENSG00000132693	ENSG00000088053
Uniprot IDs		P02741	Q9HCN6
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO	2GI7 5OU7 5OU8 5OU9
Enriched GO Terms of Interacting Partners?
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