CR1 and CR2

Number of citations of the paper that reports this interaction (PubMedID 7690834)
47

Data Source:
HPRD (in vivo)

		CR1	CR2
Description		complement C3b/C4b receptor 1 (Knops blood group)	complement C3d receptor 2
Image
GO Annotations	Cellular Component	Extracellular Space Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Secretory Granule Membrane Plasma Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane	Extracellular Space Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Virus Receptor Activity Complement Component C3b Binding Complement Component C4b Binding Complement Component C4b Receptor Activity Complement Component C3b Receptor Activity Protein Binding	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Activation Of Membrane Attack Complex Complement Receptor Mediated Signaling Pathway Immune Complex Clearance By Erythrocytes Negative Regulation Of Immunoglobulin Production Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Plasma Membrane Organization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Complement Activation Negative Regulation Of Cytolysis Negative Regulation Of Complement Activation, Alternative Pathway Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell Negative Regulation Of Serine-type Endopeptidase Activity Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Plasma Cell Differentiation ATP Export	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation Negative Regulation Of Complement Activation, Classical Pathway Viral Entry Into Host Cell
Pathways		Neutrophil degranulation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Regulation of Complement cascade	Regulation of Complement cascade
Drugs
Diseases
GWAS		Alzheimer's disease ( 21460840 19734903 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Erythrocyte sedimentation rate ( 21700265) Family history of Alzheimer's disease ( 30617256) Inflammatory biomarkers ( 22291609) Metabolite levels ( 23823483) Refractive error ( 32231278) Systemic sclerosis ( 29293537)	Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Refractive error ( 32231278) Systemic sclerosis ( 29293537) Type 2 diabetes ( 21490949)
Interacting Genes		6 interacting genes: C1QA C3 C4A CD55 CR2 FUT4	10 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53
Entrez ID		1378	1380
HPRD ID		00398	00399
Ensembl ID		ENSG00000203710	ENSG00000117322
Uniprot IDs		E9PDY4 P17927	P20023
PDB IDs		1GKG 1GKN 1GOP 1PPQ 2MCY 2MCZ 2Q7Z 5FO9	1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED
Enriched GO Terms of Interacting Partners?
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