UBLCP1 and PSMC1

Number of citations of the paper that reports this interaction (PubMedID 28539385)
8

Data Source:
BioGRID (pull down)

		UBLCP1	PSMC1
Description		ubiquitin like domain containing CTD phosphatase 1	proteasome 26S subunit, ATPase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	RNA Binding Protein Binding ATP Binding Proteasome-activating Activity
	Biological Process	Protein Dephosphorylation	Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Death Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL N-glycan trimming in the ER and Calnexin/Calreticulin cycle Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Male-pattern baldness ( 29146897) Primary biliary cholangitis ( 26394269) Serum sulfate level ( 27412988) Tuberculosis susceptibility in HIV infection ( 26942285) Ulcerative colitis ( 28067908)	Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Seasonality and depression ( 30217971)
Interacting Genes		6 interacting genes: PAAF1 PSMC1 PSMC4 PSMC5 PSMD2 TSC22D4	39 interacting genes: APP ATXN7 CCDC85B CCND3 CNOT7 CRK FBLN5 FKBP8 HSPB1 JMJD1C JMJD6 KDM1A LINC01554 LNX1 MAGEA2 MAGEA2B MEOX2 MORF4L1 OGT PAAF1 PAX4 PIAS3 PRKN PSMA7 PSMC2 PSMC4 PSMC5 PSMD2 PSMD5 PSMD7 PTGER4 STMN2 SUMO2 SUV39H1 TRAF6 UBASH3A UBLCP1 VCP ZBTB8A
Entrez ID		134510	5700
HPRD ID		08318	04084
Ensembl ID		ENSG00000164332	ENSG00000100764
Uniprot IDs		Q8WVY7	P62191 Q53XL8
PDB IDs		2KX3 2LGD 2M17	5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN
Enriched GO Terms of Interacting Partners?
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