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PSMC1 and PTGER4
Number of citations of the paper that reports this interaction (PubMedID
28298427
)
23
Data Source:
BioGRID
(two hybrid)
PSMC1
PTGER4
Description
proteasome 26S subunit, ATPase 1
prostaglandin E receptor 4
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Plasma Membrane
Integral Component Of Membrane
Molecular Function
RNA Binding
Protein Binding
ATP Binding
Proteasome-activating Activity
Prostaglandin E Receptor Activity
Protein Binding
Biological Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Death
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Cytokine Production
Positive Regulation Of Cytokine Production
Inflammatory Response
Immune Response
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
JNK Cascade
Response To Mechanical Stimulus
Regulation Of Ossification
Response To Lipopolysaccharide
Negative Regulation Of Integrin Activation
T-helper Cell Differentiation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Regulation Of Stress Fiber Assembly
Bone Development
ERK1 And ERK2 Cascade
Cellular Response To Mechanical Stimulus
Cellular Response To Prostaglandin E Stimulus
Negative Regulation Of Eosinophil Extravasation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Prostanoid ligand receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Dinoprostone
Misoprostol
Limaprost
Castor oil
Grapiprant
Diseases
GWAS
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Seasonality and depression (
30217971
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Ankylosing spondylitis (
23749187
21743469
)
Aspartate aminotransferase levels (
33547301
)
Blood urea nitrogen levels (
31152163
)
Colorectal cancer or advanced adenoma (
30510241
)
Crohn's disease (
18587394
17684544
22936669
22412388
26278503
21102463
)
Gastric cancer (
22037551
26098866
)
Inflammatory bowel disease (
23128233
)
Multiple sclerosis (
19525953
21833088
22570697
28445677
)
Pediatric autoimmune diseases (
26301688
)
Red blood cell count (
32888494
)
Selective IgA deficiency (
27723758
)
Self-reported allergy (
23817569
)
Serum urea levels (
30808845
)
Type 1 diabetes (
34127860
)
Ulcerative colitis (
21297633
)
Interacting Genes
39 interacting genes:
APP
ATXN7
CCDC85B
CCND3
CNOT7
CRK
FBLN5
FKBP8
HSPB1
JMJD1C
JMJD6
KDM1A
LINC01554
LNX1
MAGEA2
MAGEA2B
MEOX2
MORF4L1
OGT
PAAF1
PAX4
PIAS3
PRKN
PSMA7
PSMC2
PSMC4
PSMC5
PSMD2
PSMD5
PSMD7
PTGER4
STMN2
SUMO2
SUV39H1
TRAF6
UBASH3A
UBLCP1
VCP
ZBTB8A
43 interacting genes:
ACTN4
ACY3
ANAPC7
ATXN10
BIN1
BNIP1
CDPF1
CFAP298
CRADD
CRY2
CTNND2
DPF1
DST
EHMT2
FEM1A
GJC2
HMOX1
HMOX2
HOPX
KLC1
NISCH
NUBP2
NUP153
PDLIM1
PMPCB
PPP1R3F
PRDX1
PSMC1
PTPRA
RNF220
RTF2
SLBP
SLC39A8
SND1
SPP1
ST13
SUGT1
TCHH
TMEM161A
TRAP1
VSTM2A
WDR19
ZNF337
Entrez ID
5700
5734
HPRD ID
04084
03350
Ensembl ID
ENSG00000100764
ENSG00000171522
Uniprot IDs
P62191
Q53XL8
A0PJF5
P35408
PDB IDs
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
5YHL
5YWY
7D7M
Enriched GO Terms of Interacting Partners
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