TTC8 and PTPN21

		TTC8	PTPN21
Description		tetratricopeptide repeat domain 8	protein tyrosine phosphatase non-receptor type 21
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Cilium Photoreceptor Connecting Cilium BBSome Ciliary Basal Body Ciliary Membrane Non-motile Cilium	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Establishment Of Planar Polarity Axon Guidance Sensory Perception Of Smell Protein Transport Olfactory Bulb Development Regulation Of Protein Localization Negative Regulation Of GTPase Activity Multicellular Organism Growth Establishment Of Epithelial Cell Apical/basal Polarity Fat Cell Differentiation Establishment Of Anatomical Structure Orientation Sensory Processing Regulation Of Stress Fiber Assembly Inner Ear Receptor Cell Stereocilium Organization Camera-type Eye Photoreceptor Cell Differentiation Cilium Assembly Renal Tubule Development Protein Localization To Plasma Membrane Multi-ciliated Epithelial Cell Differentiation Non-motile Cilium Assembly	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Copper levels ( 26025379) Limited cutaneous systemic scleroderma ( 29293537) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		2 interacting genes: PCM1 PTPN21	28 interacting genes: AKAP1 BAG3 BMX CATSPER1 CWC22 ERBB4 FAM214B FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 TTC8 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		123016	11099
HPRD ID		10484	04468
Ensembl ID		ENSG00000165533	ENSG00000070778
Uniprot IDs		A0A0C4DGH8 A0A0C4DGX9 A0A0C4DGY3 B3KSL8 Q86U25 Q8TAM2	Q16825
PDB IDs		6XT9
Enriched GO Terms of Interacting Partners?
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