PTPN21 and TTC8

		PTPN21	TTC8
Description		protein tyrosine phosphatase non-receptor type 21	tetratricopeptide repeat domain 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Centrosome Cytosol Cilium Photoreceptor Connecting Cilium BBSome Ciliary Basal Body Ciliary Membrane Non-motile Cilium
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Establishment Of Planar Polarity Axon Guidance Sensory Perception Of Smell Protein Transport Olfactory Bulb Development Regulation Of Protein Localization Negative Regulation Of GTPase Activity Multicellular Organism Growth Establishment Of Epithelial Cell Apical/basal Polarity Fat Cell Differentiation Establishment Of Anatomical Structure Orientation Sensory Processing Regulation Of Stress Fiber Assembly Inner Ear Receptor Cell Stereocilium Organization Camera-type Eye Photoreceptor Cell Differentiation Cilium Assembly Renal Tubule Development Protein Localization To Plasma Membrane Multi-ciliated Epithelial Cell Differentiation Non-motile Cilium Assembly
Pathways			BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Copper levels ( 26025379) Limited cutaneous systemic scleroderma ( 29293537) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Obesity-related traits ( 23251661) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		28 interacting genes: AKAP1 BAG3 BMX CATSPER1 CWC22 ERBB4 FAM214B FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 TTC8 UBASH3B VPS26C YAP1 ZNF497	2 interacting genes: PCM1 PTPN21
Entrez ID		11099	123016
HPRD ID		04468	10484
Ensembl ID		ENSG00000070778	ENSG00000165533
Uniprot IDs		Q16825	A0A0C4DGH8 A0A0C4DGX9 A0A0C4DGY3 B3KSL8 Q86U25 Q8TAM2
PDB IDs			6XT9
Enriched GO Terms of Interacting Partners?
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