SP7 and KRT72

		SP7	KRT72
Description		Sp7 transcription factor	keratin 72
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Cytosol Keratin Filament Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding DEAD/H-box RNA Helicase Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Positive Regulation Of Stem Cell Differentiation	Biological_process
Pathways		RUNX2 regulates osteoblast differentiation	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bone mineral density (spine) ( 19079262 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hypospadias (moderate to severe) ( 31856834) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Serum alkaline phosphatase levels ( 33547301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	High density lipoprotein cholesterol levels ( 30498476)
Interacting Genes		9 interacting genes: CBL CBLB FAM124B FBXW7 GAS8 KRT72 MAPK14 QARS1 TRIM62	27 interacting genes: BCDIN3D BLOC1S6 HSPB1 KRT13 KRT14 KRT15 KRT16 KRT17 KRT18 KRT19 KRT20 KRT24 KRT25 KRT27 KRT31 KRT32 KRT33B KRT35 KRT38 KRT40 KRT74 KRT78 KRT80 LARP4 MYL6B SP7 TAMALIN
Entrez ID		121340	140807
HPRD ID		05971	09746
Ensembl ID		ENSG00000170374	ENSG00000170486
Uniprot IDs		A0A024RAY8 Q8TDD2	Q14CN4
PDB IDs
Enriched GO Terms of Interacting Partners?
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