CLU and TNIK

  • Number of citations of the paper that reports this interaction (PubMedID 17043677)
  • 193
  • Data Source:
  • BioGRID (two hybrid)

CLU

TNIK

Description clusterin TRAF2 and NCK interacting kinase
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Alzheimer's disease ( 19734902 19734903 21627779 31473137)
  • Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976)
  • Alzheimer's disease in APOE e4+ carriers ( 25778476)
  • Alzheimer's disease in APOE e4- carriers ( 25778476)
  • Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256)
  • Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717)
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Family history of Alzheimer's disease ( 30617256)
  • Lung adenocarcinoma ( 28604730)
  • Lung cancer in ever smokers ( 28604730)
  • Panic disorder ( 19165232)
  • Refractive error ( 32231278)
  • Schizophrenia ( 25056061 29483656)
  • Smoking behaviour (cigarettes smoked per day) ( 31089300)
  • Smoking initiation ( 33082346)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Spherical equivalent or myopia (age of diagnosis) ( 29808027)
  • Adolescent idiopathic scoliosis ( 28334814)
  • Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125)
  • Brain morphology (min-P) ( 32665545)
  • Brain morphology (MOSTest) ( 32665545)
  • Cerebrospinal fluid AB1-42 levels ( 29274321)
  • Change in serum metabolite levels ( 31636271)
  • Change in serum metabolite levels (CMS) ( 31636271)
  • Cortical surface area (MOSTest) ( 32665545)
  • Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136)
  • Frontotemporal dementia (age at onset) ( 29724592)
  • Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
  • Hip circumference adjusted for BMI ( 28552196)
  • LDL cholesterol ( 21347282)
  • Lymphocyte counts ( 32888494 27863252)
  • Lymphocyte percentage of white cells ( 32888494)
  • Night sleep phenotypes ( 27126917)
  • Response to antipsychotic treatment in schizophrenia ( 29503163)
  • Subcortical volume (MOSTest) ( 32665545)
  • Triglyceride levels ( 32154731)
  • Type 2 diabetes ( 30054458)
Interacting Genes 59 interacting genes: ADGRF4 APP BAG6 C7 C8B C9 CBR3 CBY1 CD209 CLUAP1 CYP2E1 DISC1 DLG4 DUSP13 ELN EPPIN FOS GEMIN7 GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN KRT12 LEP LEPR LIG4 LRP1 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 NAT2 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 SHANK3 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT 37 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID 1191 23043
HPRD ID 01706 18206
Ensembl ID ENSG00000120885 ENSG00000154310
Uniprot IDs P10909 Q9UKE5
PDB IDs 2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?