CLCNKA and KLHL20

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLCNKA	KLHL20
Description		chloride voltage-gated channel Ka	kelch like family member 20
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Voltage-gated Chloride Channel Activity Identical Protein Binding Metal Ion Binding	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding
	Biological Process	Chloride Transport Excretion Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Ubiquitination
Pathways		Stimuli-sensing channels	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Niflumic acid Talniflumate
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular ejection fraction ( 33495596 32382064) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Waist circumference adjusted for body mass index ( 28552196)	Feeling miserable ( 29500382)
Interacting Genes		22 interacting genes: C7orf31 CYSRT1 IKZF3 KLHL20 KPRP KRT31 KRT34 KRT37 KRT39 KRTAP21-2 KRTAP4-12 KRTAP6-3 LHX3 MBD3L1 PBX4 SLITRK5 SRPK2 TCF12 TCF4 TEPSIN TRIB3 ZNF511	42 interacting genes: ACTA1 ARHGEF12 ATG9A BCL6 BEX1 BEX2 BRINP2 C1orf216 C20orf85 C21orf58 CEP126 CIDEC CLCNKA COL8A1 CORO7 CRK CRMP1 DUSP21 ECT2 ENKD1 EPAS1 ERG28 GBP2 HR IVNS1ABP KLHL38 LRIF1 LUC7L2 MTNR1A NEDD9 NTAQ1 PIN1 PML PRMT6 RANBP3 RECK SLC13A5 STK16 SUV39H1 TFAP2D TNPO2 USP20
Entrez ID		1187	27252
HPRD ID		03608	13918
Ensembl ID		ENSG00000186510	ENSG00000076321
Uniprot IDs		P51800	Q9Y2M5
PDB IDs		2PFI	5YQ4 6GY5
Enriched GO Terms of Interacting Partners?
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