RMI2 and FANCM

Number of citations of the paper that reports this interaction (PubMedID 20064461)
120

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RMI2	FANCM
Description		RecQ mediated genome instability 2	FA complementation group M
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Nuclear Speck	Nucleoplasm Fanconi Anaemia Nuclear Complex FANCM-MHF Complex
	Molecular Function	DNA Binding Protein Binding	Four-way Junction DNA Binding Chromatin Binding RNA Helicase Activity Nuclease Activity Protein Binding ATP Binding Four-way Junction Helicase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	DNA Replication DNA Repair Regulation Of Sister Chromatid Segregation Maintenance Of RDNA Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Resolution Of Meiotic Recombination Intermediates Replication Fork Processing DNA Duplex Unwinding Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Replication Fork Reversal Nucleic Acid Phosphodiester Bond Hydrolysis Positive Regulation Of Protein Monoubiquitination
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Fanconi Anemia Pathway
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 25961943) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 24076602) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Vein graft stenosis in coronary artery bypass grafting ( 25881214)	Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		2 interacting genes: FANCM NOTCH3	11 interacting genes: APP CENPX ECT2 EME2 EPN2 FAAP24 LRRK2 RMI1 RMI2 TRIM27 UBE2I
Entrez ID		116028	57697
HPRD ID		14497	13876
Ensembl ID		ENSG00000175643	ENSG00000187790
Uniprot IDs		Q96E14	Q8IYD8
PDB IDs		3MXN 3NBH 4DAY	4BXO 4DAY 4DRB 4E45 4M6W
Enriched GO Terms of Interacting Partners?
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