TRIM9 and EVL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TRIM9	EVL
Description		tripartite motif containing 9	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Dendrite	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		33 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DNAAF2 DTNBP1 DTX3L EVL FAM124B FAM90A1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID NTAQ1 PCGF3 RNF166 RPL4P5 SHANK3 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 UTP25 VASP	45 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP ATG2B BDKRB1 BEGAIN C14orf132 CKB CRKL DNMBP ENAH F11R FXR1 FXR2 FYB1 FYN GSKIP HCK HTT KRT17 KRT34 LRP1B LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		114088	51466
HPRD ID		05947	10942
Ensembl ID		ENSG00000100505	ENSG00000196405
Uniprot IDs		Q9C026	A0A024R6K5 Q9UI08
PDB IDs		2DB8 7B2S
Enriched GO Terms of Interacting Partners?
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