CHRNA1 and CHRNE

Number of citations of the paper that reports this interaction (PubMedID 1712080)
15

Data Source:
HPRD (in vitro)

		CHRNA1	CHRNE
Description		cholinergic receptor nicotinic alpha 1 subunit	cholinergic receptor nicotinic epsilon subunit
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Cell Surface Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane Integral Component Of Postsynaptic Specialization Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuromuscular Junction Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Cation Transmembrane Transporter Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Skeletal Muscle Contraction Cation Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Neuromuscular Junction Development Neuronal Action Potential Ion Transmembrane Transport Regulation Of Membrane Potential Muscle Cell Cellular Homeostasis Skeletal Muscle Tissue Growth Nervous System Process Musculoskeletal Movement Neuromuscular Process Excitatory Postsynaptic Potential Neuron Cellular Homeostasis	Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential Cation Transmembrane Transport
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs		Lamotrigine Agmatine
Diseases
GWAS		Atrial fibrillation ( 29892015)	Alzheimer's disease ( 34099642) Keratoconus ( 33649486) Platelet count ( 29403010)
Interacting Genes		5 interacting genes: CHRND CHRNE CHRNG ITGA7 LILRB3	2 interacting genes: CHRNA1 DUSP6
Entrez ID		1134	1145
HPRD ID		00007	00008
Ensembl ID		ENSG00000138435	ENSG00000108556
Uniprot IDs		P02708 Q53SH4	Q04844
PDB IDs		1Y5P 1Y5T 1Y6C 4ZJS 5HBT	2DF9
Enriched GO Terms of Interacting Partners?
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