CBX3 and MKI67

Number of citations of the paper that reports this interaction (PubMedID 12485163)
10

Data Source:
BioGRID (proximity labelling technology)
HPRD (two hybrid, in vitro)

		CBX3	MKI67
Description		chromobox 3	marker of proliferation Ki-67
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage	Condensed Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Membrane Nuclear Body
	Molecular Function	Transcription Coregulator Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding	DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding
	Biological Process	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process	Cell Cycle Regulation Of Mitotic Nuclear Division Cell Population Proliferation Regulation Of Chromosome Segregation Regulation Of Chromatin Organization
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alzheimer's disease in APOE e4- carriers ( 25778476) Drug experimentation measurement ( 30718321) Lead levels ( 26025379) Select biomarker traits ( 17903293) Suicide attempt severity in mood disorders ( 33783297) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		44 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 PRR14 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280C ZNF280D ZNF496	15 interacting genes: CBX3 CBX5 CDK1 DRD4 ECPAS HINFP KIF15 NIFK PRKCB PTEN SMN1 SUMO2 TK1 TRIM55 TRIM63
Entrez ID		11335	4288
HPRD ID		05130	08902
Ensembl ID		ENSG00000122565	ENSG00000148773
Uniprot IDs		A4D177 Q13185	P46013
PDB IDs		2L11 3DM1 3KUP 3TZD 5T1I 6HW2	1R21 2AFF 5J28
Enriched GO Terms of Interacting Partners?
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