MKI67 and CBX5

Number of citations of the paper that reports this interaction (PubMedID 12485163)
10

Data Source:
HPRD (two hybrid, in vitro)

		MKI67	CBX5
Description		marker of proliferation Ki-67	chromobox 5
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Chromosome Nucleolus Membrane Nuclear Body	Histone Deacetylase Complex Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding	Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding DNA-binding Transcription Factor Binding
	Biological Process	Cell Cycle Regulation Of Mitotic Nuclear Division Cell Population Proliferation Regulation Of Chromosome Segregation Regulation Of Chromatin Organization	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated
Pathways			SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs			Copper
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Drug experimentation measurement ( 30718321) Lead levels ( 26025379) Select biomarker traits ( 17903293) Suicide attempt severity in mood disorders ( 33783297) Triglyceride levels x loop diuretics use interaction ( 31806883)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: CBX3 CBX5 CDK1 DRD4 ECPAS HINFP KIF15 NIFK PRKCB PTEN SMN1 SUMO2 TK1 TRIM55 TRIM63	60 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FES FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		4288	23468
HPRD ID		08902	05131
Ensembl ID		ENSG00000148773	ENSG00000094916
Uniprot IDs		P46013	P45973 V9HWG0
PDB IDs		1R21 2AFF 5J28	3FDT 3I3C
Enriched GO Terms of Interacting Partners?
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