GPR182 and ITGA5

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		GPR182	ITGA5
Description		G protein-coupled receptor 182	integrin subunit alpha 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Ruffle Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex Cell Surface Ruffle Membrane Integrin Alpha5-beta1 Complex Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity	Virus Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway	Angiogenesis Cell Adhesion Integrin-mediated Signaling Pathway CD40 Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis
Pathways			Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration
Drugs			Resveratrol
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Heel bone mineral density ( 28869591) Refractive error ( 32231278)	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: ABHD12 GOSR1 HLA-C INHBE ITGA5 MPG OGFR PLPPR3 TMEM101 TMEM30A TMUB2	33 interacting genes: ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CHMP2A CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GPR182 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP THAP1 TNC UBAP1 VCL
Entrez ID		11318	3678
HPRD ID		05605	00627
Ensembl ID		ENSG00000166856	ENSG00000161638
Uniprot IDs		O15218	B2R627 P08648
PDB IDs			3VI3 3VI4 4WJK 4WK0 4WK2 4WK4
Enriched GO Terms of Interacting Partners?
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