VPS45 and VPS11

Number of citations of the paper that reports this interaction (PubMedID 14623309)
7

Data Source:
HPRD (in vivo)

		VPS45	VPS11
Description		vacuolar protein sorting 45 homolog	VPS11 core subunit of CORVET and HOPS complexes
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cellular_component Golgi Apparatus Synaptic Vesicle Endosome Membrane Integral Component Of Membrane	Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Clathrin-coated Vesicle Endocytic Vesicle HOPS Complex Late Endosome Membrane
	Molecular Function	Molecular_function Protein Binding	Nucleotide Binding Protein Binding Protein Domain Specific Binding Syntaxin Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Autophagy Endosome Organization Vacuole Organization Endosome To Lysosome Transport Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Endosomal Vesicle Fusion Organelle Fusion Regulation Of Organelle Assembly Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Intra-Golgi traffic Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hip circumference adjusted for BMI ( 34021172) Obesity in adult survivors of childhood cancer not exposed to cranial radiation ( 25963547) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Uric acid levels ( 21294900)	Adult body size ( 32376654) Body mass index ( 29273807) Coronary artery disease ( 29212778 33020668) HDL cholesterol levels ( 32203549) Plateletcrit ( 32888494)
Interacting Genes		16 interacting genes: BCAR3 C1orf43 CASP8 H2AC18 IGF1R PAX2 PTPN1 RAB13 RB1CC1 RBSN RPRD2 SNTG1 STX16 SV2A VPS11 VPS18	38 interacting genes: ALG9 BCAR1 BMI1 ECPAS EZR FUT1 GGA3 KDM1A KRTAP10-3 KRTAP10-8 LRSAM1 LSM1 MALL MARK3 MON1B MSN RAB7A RDX RILP RNF181 RNF26 STX1A STX6 STX7 STX8 TFAP2B TRIM32 TSG101 UBE2D2 UBE2L3 UBE2U UVRAG VPS16 VPS18 VPS33A VPS39 VPS45 WNT1
Entrez ID		11311	55823
HPRD ID		10301	12258
Ensembl ID		ENSG00000136631	ENSG00000160695
Uniprot IDs		A0A2R8YE10 B7Z360 B7Z5D4 Q9NRW7	A0A087WXL6 B7Z879 Q9H270
PDB IDs
Enriched GO Terms of Interacting Partners?
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