RWDD2A and ARHGEF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

		RWDD2A	ARHGEF6
Description		RWD domain containing 2A	Rac/Cdc42 guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component		Cytosol Lamellipodium
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process		Apoptotic Process JNK Cascade Lamellipodium Assembly Regulation Of Catalytic Activity
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS			Breast cancer ( 29059683)
Interacting Genes		5 interacting genes: ARHGEF6 ERBB3 MCMBP PSMB1 SNAP91	38 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 CDK6 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		112611	9459
HPRD ID		15287	02226
Ensembl ID		ENSG00000013392	ENSG00000129675
Uniprot IDs		B2R7R2 B4DZK9 Q9UIY3	B7Z3C7 Q15052 Q8N4Q3
PDB IDs		2DAW	1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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