CHKA and DEPTOR

Number of citations of the paper that reports this interaction (PubMedID 22017875)
132

Data Source:
BioGRID (enzymatic study)

		CHKA	DEPTOR
Description		choline kinase alpha	DEP domain containing MTOR interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Choline Kinase Activity Cholinesterase Activity Ethanolamine Kinase Activity ATP Binding Choline Binding Identical Protein Binding	Protein Binding
	Biological Process	Ethanolamine Metabolic Process Lipid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process CDP-choline Pathway Lipid Transport Response To Toxic Substance Phosphorylation Choline Metabolic Process Response To 3-methylcholanthrene	Negative Regulation Of Protein Kinase Activity Negative Regulation Of TOR Signaling Intracellular Signal Transduction Negative Regulation Of Cell Size Negative Regulation Of TORC2 Signaling Negative Regulation Of TORC1 Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Synthesis of PC Synthesis of PE
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 33730874)	Body shape index ( 34021172) Choroid plexus volume ( 31530798) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Idiopathic pulmonary fibrosis ( 31710517) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 33230300) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		6 interacting genes: APP DEPTOR FCHSD2 PSEN2 RCC1 SKP2	13 interacting genes: ANKRD11 APP BTRC CCDC110 CHKA CUL5 FBXO25 LNX1 PSME3 RPS6KA1 RPS6KB1 TRAF1 TRIM41
Entrez ID		1119	64798
HPRD ID		00327	13137
Ensembl ID		ENSG00000110721	ENSG00000155792
Uniprot IDs		P35790	Q8TB45
PDB IDs		2CKO 2CKP 2CKQ 2I7Q 3F2R 3G15 3ZM9 4BR3 4CG8 4CG9 4CGA 4DA5 5AFV 5EQE 5EQP 5EQY 5FTG 5FUT 5W6O 7A04 7A06
Enriched GO Terms of Interacting Partners?
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