HCLS1 and HS1BP3

Number of citations of the paper that reports this interaction (PubMedID 10590261)
8

Data Source:
HPRD (in vivo)

		HCLS1	HS1BP3
Description		hematopoietic cell-specific Lyn substrate 1	HCLS1 binding protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Actin Filament Plasma Membrane Site Of Polarized Growth Cortical Actin Cytoskeleton	Mitochondrion Endoplasmic Reticulum
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Binding Phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Population Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization	Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS			Diverticular disease ( 30177863) Low density lipoprotein cholesterol levels ( 29403010) Total cholesterol levels ( 29403010) Waist-hip ratio ( 28552196)
Interacting Genes		24 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25	2 interacting genes: HCLS1 ZDHHC17
Entrez ID		3059	64342
HPRD ID		03199	13357
Ensembl ID		ENSG00000180353	ENSG00000118960
Uniprot IDs		P14317	Q53T59 Q9H7U7
PDB IDs
Enriched GO Terms of Interacting Partners?
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