DMC1 and RAD51AP1

Number of citations of the paper that reports this interaction (PubMedID 21307306)
24

Data Source:
BioGRID (affinity chromatography technology, pull down, biochemical)

		DMC1	RAD51AP1
Description		DNA meiotic recombinase 1	RAD51 associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleus Chromosome	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex
	Molecular Function	DNA Strand Exchange Activity DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Identical Protein Binding	DNA Secondary Structure Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding D-loop DNA Binding
	Biological Process	DNA Recombinase Assembly Ovarian Follicle Development Oocyte Maturation Mitotic Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiosis I Spermatogenesis Spermatid Development Female Gamete Generation Strand Invasion Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle	Double-strand Break Repair Via Homologous Recombination DNA Repair Cellular Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Reciprocal Meiotic Recombination Interstrand Cross-link Repair Meiotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Meiotic recombination	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs		Imidazole
Diseases
GWAS		Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Menopause (age at onset) ( 26414677) Sleep duration ( 30846698)	Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)
Interacting Genes		19 interacting genes: BRCA2 C1orf112 FIGNL1 GORASP2 KCTD17 LNX1 MSH4 NIF3L1 PIAS2 PICK1 PSMA3 RAD51 RAD51AP1 RAD54B RPA1 SDCBP SDCBP2 TRIM23 UBE2I	9 interacting genes: APP CACNA1C DMC1 LRRK2 MAP3K1 NEDD4 PALB2 RAD51 SIAH1
Entrez ID		11144	10635
HPRD ID		04099	04350
Ensembl ID		ENSG00000100206	ENSG00000111247
Uniprot IDs		Q14565	Q96B01
PDB IDs		1V5W 2ZJB 4HYY 6R3P 7C98 7C99 7C9C 7CGY
Enriched GO Terms of Interacting Partners?
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