RAD51AP1 and DMC1

Number of citations of the paper that reports this interaction (PubMedID 21307306)
24

Data Source:
BioGRID (affinity chromatography technology, pull down, biochemical)

		RAD51AP1	DMC1
Description		RAD51 associated protein 1	DNA meiotic recombinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nucleus Chromosome
	Molecular Function	DNA Secondary Structure Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding D-loop DNA Binding	DNA Strand Exchange Activity DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Identical Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Cellular Response To DNA Damage Stimulus Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Reciprocal Meiotic Recombination Interstrand Cross-link Repair Meiotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination	DNA Recombinase Assembly Ovarian Follicle Development Oocyte Maturation Mitotic Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiosis I Spermatogenesis Spermatid Development Female Gamete Generation Strand Invasion Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Meiotic recombination
Drugs			Imidazole
Diseases
GWAS		Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)	Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Menopause (age at onset) ( 26414677) Sleep duration ( 30846698)
Interacting Genes		9 interacting genes: APP CACNA1C DMC1 LRRK2 MAP3K1 NEDD4 PALB2 RAD51 SIAH1	19 interacting genes: BRCA2 C1orf112 FIGNL1 GORASP2 KCTD17 LNX1 MSH4 NIF3L1 PIAS2 PICK1 PSMA3 RAD51 RAD51AP1 RAD54B RPA1 SDCBP SDCBP2 TRIM23 UBE2I
Entrez ID		10635	11144
HPRD ID		04350	04099
Ensembl ID		ENSG00000111247	ENSG00000100206
Uniprot IDs		Q96B01	Q14565
PDB IDs			1V5W 2ZJB 4HYY 6R3P 7C98 7C99 7C9C 7CGY
Enriched GO Terms of Interacting Partners?
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