CDK7 and HSD17B4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CDK7	HSD17B4
Description		cyclin dependent kinase 7	hydroxysteroid 17-beta dehydrogenase 4
Image
GO Annotations	Cellular Component	Transcription Factor TFIIH Core Complex Fibrillar Center Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex Cytoplasm Cytosol Plasma Membrane Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex Perinuclear Region Of Cytoplasm CAK-ERCC2 Complex Transcription Factor TFIIK Complex	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Serine Kinase Activity	3-hydroxyacyl-CoA Dehydrogenase Activity Enoyl-CoA Hydratase Activity Long-chain-enoyl-CoA Hydratase Activity Isomerase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Cell Cycle SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Cell Division Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Fatty Acid Beta-oxidation Androgen Metabolic Process Estrogen Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Sertoli Cell Development
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Phosphonothreonine Alvocidib SNS-032 Seliciclib	NADH (R)-3-hydroxydecanoyl-CoA
Diseases
GWAS			Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) JT interval (sulfonylurea treatment interaction) ( 27958378) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) QT interval (sulfonylurea treatment interaction) ( 27958378) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		45 interacting genes: ADAMTS6 APP AR BRCA1 CCND2 CCNH CDC37 CDK1 CDK2 CDK6 CDK9 CTDP1 CUX1 E2F1 ERCC2 ERCC3 ESR1 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H5 H1-1 HLA-DQA1 HSD17B4 LASP1 MBP MCM7 MNAT1 NEK6 PCGF6 POLR2B PRKCI RARA SMAD1 SRPK1 SRPK2 SUPT5H TAF7 TCEA1 THRA TP53 UBE2D1 VDR	8 interacting genes: ACTB BAK1 CASP9 CDK7 FER MAPK8 NDRG1 SNCA
Entrez ID		1022	3295
HPRD ID		15993	03514
Ensembl ID		ENSG00000134058	ENSG00000133835
Uniprot IDs		A0A0S2Z3F9 D6R9G1 D6RFL0 P50613	A0A0S2Z4J1 B2R659 B3KSP2 P51659
PDB IDs		1LG3 1PA8 1UA2 2HIC 6O9L 6XBZ 6XD3 7B5O 7B5Q	1IKT 1S9C 1ZBQ 6Z1W 6Z1X
Enriched GO Terms of Interacting Partners?
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