WWP1 and TGIF1

Number of citations of the paper that reports this interaction (PubMedID 18511908)
13

Data Source:
HPRD (in vivo)

		WWP1	TGIF1
Description		WW domain containing E3 ubiquitin protein ligase 1	TGFB induced factor homeobox 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Chromatin Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Co-SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Periodontitis (DPAL) ( 24024966) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		58 interacting genes: ARRDC1 ARRDC2 ARRDC3 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 DVL2 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 MIR19A MIR19B1 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 PRRG4 PYGM RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SHANK3 SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WASL WBP1 WBP2 YWHAQ ZNF638	21 interacting genes: A2M APP AR CTBP1 CTBP2 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 MOB3A PML SIN3A SMAD2 SMAD3 WWP1
Entrez ID		11059	7050
HPRD ID		03811	04023
Ensembl ID		ENSG00000123124	ENSG00000177426
Uniprot IDs		Q9H0M0	Q15583
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	2LK2 6FQP 6FQQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?