KDELR2 and LATS2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (fluorescent resonance energy transfer)

		KDELR2	LATS2
Description		KDEL endoplasmic reticulum protein retention receptor 2	large tumor suppressor kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cis-Golgi Network Integral Component Of Membrane Transport Vesicle COPI-coated Vesicle Membrane	Spindle Pole Nucleus Cytosol Centriolar Satellite
	Molecular Function	KDEL Sequence Binding ER Retention Sequence Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Retention In ER Lumen Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport	G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Signaling by Hippo
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Blood protein levels ( 29875488) Body mass index ( 26426971) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 25248455) Lymphocyte percentage of white cells ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)
Interacting Genes		22 interacting genes: AKT1 BECN1 CCND2 CD44 CDK4 CDK6 CDKN2B EPHA2 ERBB2 FGFR4 GRM1 IGF1R KAT2A LATS2 MAP2K3 MET MYC NF2 PDGFRA RASSF1 STK11 TTYH2	68 interacting genes: ABL1 AJUBA AKT1 ARAF ARNT AURKA AURKB BECN1 BRAF CBLC CCND2 CCNE1 CD44 CDK2 CDK4 CDK6 CDKN1A CDKN2A CDKN2B CDKN2C CHEK1 CHEK2 CTNNB1 DYRK1A EPHA2 ERBB2 EZH2 FGFR4 FHL3 FLT1 FZR1 GLIS1 GLIS2 GRAP2 GRM1 HGF HIF1A KAT2A KDELR2 KIF23 MAP2K3 MAP2K5 MAPK14 MDM4 MET MOB3A MOB3B MOB3C MOB4 MYC NF2 NFIC PDGFRA RAF1 RASSF1 RELA SMAD2 SNAI1 STK11 STK3 SUZ12 TAFAZZIN TEAD2 TP53 TSC1 WWTR1 YWHAG YWHAZ
Entrez ID		11014	26524
HPRD ID		06598	07277
Ensembl ID		ENSG00000136240	ENSG00000150457
Uniprot IDs		A0A024QZT7 P33947	A0A024RDM3 Q9NRM7
PDB IDs			4ZRI
Enriched GO Terms of Interacting Partners?
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