SLC38A3 and TNFSF14

		SLC38A3	TNFSF14
Description		solute carrier family 38 member 3	TNF superfamily member 14
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	L-histidine Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-asparagine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity Symporter Activity Antiporter Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Amino Acid Transmembrane Transport Sodium Ion Transport Amino Acid Transport Asparagine Transport Glutamine Transport Brain Development Female Pregnancy L-alanine Transport Histidine Transport Cellular Response To Potassium Ion Starvation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Acidic PH L-histidine Transmembrane Transport Transport Across Blood-brain Barrier Positive Regulation Of Glutamine Transport	Apoptotic Process Immune Response Signal Transduction T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Amino acid transport across the plasma membrane	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Histidine Asparagine
Diseases
GWAS		Body mass index ( 26426971) Conotruncal heart defects (maternal effects) ( 28468790) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sleep duration (short sleep) ( 30846698) Smoking status (ever vs never smokers) ( 30643258)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)
Interacting Genes		4 interacting genes: COL6A2 HMGN1 SETDB1 TNFSF14	25 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP S1PR4 SEC22A SEC23A SLC38A3 SYS1 TCF3 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		10991	8740
HPRD ID		11980	05157
Ensembl ID		ENSG00000188338	ENSG00000125735
Uniprot IDs		Q99624	O43557
PDB IDs			4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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