GIPC1 and TYRP1

Number of citations of the paper that reports this interaction (PubMedID 11441007)
23

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GIPC1	TYRP1
Description		GIPC PDZ domain containing family member 1	tyrosinase related protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytoplasm Endosome Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome Intracellular Vesicle
	Molecular Function	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Identical Protein Binding Cadherin Binding	Tyrosinase Activity Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Regulation Of Synaptic Vesicle Exocytosis	Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Positive Regulation Of Melanin Biosynthetic Process
Pathways			Melanin biosynthesis
Drugs
Diseases
GWAS		Kidney stones ( 31729369)	Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 18488028) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eye color ( 23548203 33692100 30664655) Eye color (brightness) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 30166351) Hair color ( 22556244 29662168) Low tan response ( 29739929) Metabolite levels ( 23823483) Mild to moderate chronic kidney disease ( 31178898) Mitochondrial DNA copy number ( 30704525) Neuroticism ( 27089181) Nevus count or cutaneous melanoma ( 32341527) Psoriasis ( 30921485) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Skin pigmentation ( 29195075) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		37 interacting genes: ACTN1 ADRB1 BRD4 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SH3BP4 SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408	3 interacting genes: GIPC1 SEC22A TYR
Entrez ID		10755	7306
HPRD ID		05462	00283
Ensembl ID		ENSG00000123159	ENSG00000107165
Uniprot IDs		A0A024R7I0 A0A024R7I1 A8K2I7 O14908	P17643
PDB IDs			5M8L 5M8M 5M8N 5M8O 5M8P 5M8Q 5M8R 5M8S 5M8T
Enriched GO Terms of Interacting Partners?
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