TYRP1

Description		tyrosinase related protein 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Melanosome Membrane Melanosome Intracellular Vesicle
	Molecular Function	Tyrosinase Activity Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Melanocyte Differentiation Melanosome Organization Melanin Biosynthetic Process Acetoacetic Acid Metabolic Process Positive Regulation Of Melanin Biosynthetic Process
Pathways		Melanin biosynthesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Blue vs. green eyes ( 18488028) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eye color ( 23548203 33692100 30664655) Eye color (brightness) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 30166351) Hair color ( 22556244 29662168) Low tan response ( 29739929) Metabolite levels ( 23823483) Mild to moderate chronic kidney disease ( 31178898) Mitochondrial DNA copy number ( 30704525) Neuroticism ( 27089181) Nevus count or cutaneous melanoma ( 32341527) Psoriasis ( 30921485) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Skin pigmentation ( 29195075) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		3 interacting genes: GIPC1 SEC22A TYR
Entrez ID		7306
HPRD ID		00283
Ensembl ID		ENSG00000107165
Uniprot IDs		P17643
PDB IDs		5M8L 5M8M 5M8N 5M8O 5M8P 5M8Q 5M8R 5M8S 5M8T
Enriched GO Terms of Interacting Partners?
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