MAP3K2 and MAP2K3

Number of citations of the paper that reports this interaction (PubMedID 9162092)
26

Data Source:
BioGRID (enzymatic study)

		MAP3K2	MAP2K3
Description		mitogen-activated protein kinase kinase kinase 2	mitogen-activated protein kinase kinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleoplasm Cytosol Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	MAPK Cascade Regulation Of Cytokine Production Inflammatory Response Signal Transduction Peptidyl-tyrosine Phosphorylation Negative Regulation Of Hippo Signaling Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction Cellular Senescence
Pathways			Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs		Bosutinib Fostamatinib	Fostamatinib
Diseases
GWAS		Protein C levels ( 28082259)	Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062)
Interacting Genes		25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	54 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53
Entrez ID		10746	5606
HPRD ID		10068	03816
Ensembl ID		ENSG00000169967	ENSG00000034152
Uniprot IDs		A0A024RAH0 Q9Y2U5	P46734 Q6FI23
PDB IDs		2CU1 2NPT 5EX0 5HQ8
Enriched GO Terms of Interacting Partners?
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