MAP3K2 and NGLY1

		MAP3K2	NGLY1
Description		mitogen-activated protein kinase kinase kinase 2	N-glycanase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation ER-associated Misfolded Protein Catabolic Process
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs		Bosutinib Fostamatinib
Diseases
GWAS		Protein C levels ( 28082259)
Interacting Genes		25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ	25 interacting genes: APP BICRAL FAF1 GJB2 GRM7 GUCD1 LIMD1 MAP3K2 NPAS2 NSFL1C OPA3 PAX5 PAX6 PROC RAD23A RAD23B SH3BP1 SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID		10746	55768
HPRD ID		10068	10118
Ensembl ID		ENSG00000169967	ENSG00000151092
Uniprot IDs		A0A024RAH0 Q9Y2U5	Q96IV0
PDB IDs		2CU1 2NPT 5EX0 5HQ8	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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