KHDRBS1 and SKAP2

Number of citations of the paper that reports this interaction (PubMedID 22745667)
6

Data Source:
BioGRID (unspecified method)

		KHDRBS1	SKAP2
Description		KH RNA binding domain containing, signal transduction associated 1	src kinase associated phosphoprotein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Grb2-Sos Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Domain Specific Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein-containing Complex Binding Protein Tyrosine Kinase Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Spermatogenesis Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation Protein-containing Complex Assembly
Pathways		PTK6 Regulates Proteins Involved in RNA Processing	Signal regulatory protein family interactions
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Disease free survival in colon cancer ( 31811950) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) FEV1 ( 30804560) Hip index ( 34021172) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Survival in colon cancer ( 31811950) Systemic lupus erythematosus ( 28714469)
Interacting Genes		114 interacting genes: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK CBL CD2AP CDC42 CDK1 CIRBP CLK1 CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 EFEMP1 EMG1 FGR FNBP4 FRK FXR1 FXR2 FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITPRID2 ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OGT OSTF1 PACSIN1 PALS2 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RBMX RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SHANK3 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SRPK2 STAT3 STUB1 TBL1X TJP1 TSPOAP1 TUBB3 UBA52 UBASH3B UBC VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6	20 interacting genes: APP BLK DNAJB6 FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1
Entrez ID		10657	8935
HPRD ID		03926	05558
Ensembl ID		ENSG00000121774	ENSG00000005020
Uniprot IDs		Q07666	B7Z5R3 O75563
PDB IDs		2XA6 3QHE	3OMH
Enriched GO Terms of Interacting Partners?
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