SLU7 and DEF6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLU7	DEF6
Description		SLU7 homolog, splicing factor	DEF6 guanine nucleotide exchange factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex Intracellular Membrane-bounded Organelle Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Filopodium Perinuclear Region Of Cytoplasm
	Molecular Function	Second Spliceosomal Transesterification Activity Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Intracellular Protein Transport RNA Splicing Cellular Response To Heat	Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 32296059) Common carotid intima-media thickness ( 29206233)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Height ( 18391951 33713608) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Neutrophil count ( 32888494) Systemic lupus erythematosus ( 33493351 28714469) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		29 interacting genes: AIMP2 ARHGEF5 BAG2 CCDC85B CEP70 DEF6 FHL3 GOLGA2 GTF2I IKBKG JMJD6 KDM1A KRT40 LMNA LONRF1 LZTS2 MCC NFKBID NSD3 PCBP2 PIBF1 PPIG PPIL3 PRMT5 PRMT6 TEPSIN THAP1 ZBED8 ZCCHC10	32 interacting genes: APP ARHGAP22 BEGAIN CCDC88B CDC42 CDC42EP1 EIF4ENIF1 GOLGA6A GOLGA6L9 HOMEZ INCA1 INTS2 KIAA1328 KRT31 L3MBTL3 LCK PBXIP1 PLSCR1 PSMA1 PTK2 RAC1 RAC2 RAPGEF4 RASAL3 REL RHOA SAP18 SLU7 TCF4 TEPSIN ZAP70 ZNF688
Entrez ID		10569	50619
HPRD ID		12074	10869
Ensembl ID		ENSG00000164609	ENSG00000023892
Uniprot IDs		O95391	Q9H4E7
PDB IDs		5XJC 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?
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