UBD and SAE1

Number of citations of the paper that reports this interaction (PubMedID 31575873)
6

Data Source:
BioGRID (pull down)

		UBD	SAE1
Description		ubiquitin D	SUMO1 activating enzyme subunit 1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Protein Binding Proteasome Binding	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Interferon-gamma Response To Tumor Necrosis Factor Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Aggresome Assembly Regulation Of Mitotic Cell Cycle Phase Transition	Protein Ubiquitination Protein Sumoylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Neddylation	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		14 interacting genes: MAD2L1 NUB1 OTUB1 PDE9A PSMD4 SAE1 SRPK1 SRPK2 TGFBR1 UBA2 UBA6 UBE2D2 UBE2Z USP16	22 interacting genes: AGTR1 APP CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39
Entrez ID		10537	10055
HPRD ID		09354	18010
Ensembl ID		ENSG00000213886	ENSG00000142230
Uniprot IDs		A0A1U9X8S6 O15205	A0A024R0R4 Q9UBE0
PDB IDs		2MBE 6GF1 6GF2	1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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