ENOX2 and RNF135

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ENOX2	RNF135
Description		ecto-NOX disulfide-thiol exchanger 2	ring finger protein 135
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding Protein-disulfide Reductase Activity	Ubiquitin-protein Transferase Activity Protein Binding RIG-I Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ultradian Rhythm Electron Transport Chain Regulation Of Growth	Protein Polyubiquitination Free Ubiquitin Chain Polymerization Protein Ubiquitination Positive Regulation Of Interferon-beta Production RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Protein Homooligomerization Protein K63-linked Ubiquitination Antiviral Innate Immune Response
Pathways			DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs		Idronoxil
Diseases
GWAS		Hemoglobin ( 32888494)	Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		20 interacting genes: CDC37 CIB3 ENOX1 GORASP2 INTS4 LNX1 MAGEA11 MAGEA3 MLLT6 NDOR1 NTAQ1 RNF135 SNRPA SRPK2 STAMBPL1 TFIP11 TRAF5 TUBB4B VCL ZFP2	10 interacting genes: CTBP2 CTNNAL1 DDX58 ENOX2 GOLGA2 HSF2BP IFIH1 TEPSIN UBE2D2 UBE2N
Entrez ID		10495	84282
HPRD ID		02234	11506
Ensembl ID		ENSG00000165675	ENSG00000181481
Uniprot IDs		Q16206 Q32ND0	B3KV69 Q8IUD6
PDB IDs			7JL1 7JL3
Enriched GO Terms of Interacting Partners?
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