C1D and IL23R

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		C1D	IL23R
Description		C1D nuclear receptor corepressor	interleukin 23 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Transcription Repressor Complex	Plasma Membrane External Side Of Plasma Membrane Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	DNA Binding Transcription Corepressor Activity RNA Binding Protein Binding Nuclear Receptor Binding	Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Maturation Of 5.8S RRNA Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Interferon-gamma Interleukin-23-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs
Diseases
GWAS		Familial lung adenocarcinoma ( 29924316) Male-pattern baldness ( 27182965) Obstetric antiphospholipid syndrome ( 28424481) PR interval ( 32439900) Restless legs syndrome ( 29029846) Schizophrenia x sex interaction ( 34099189) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187 21743469 20062062) Behcet's disease ( 20622878 20622879 33393726) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 28067908 20570966 22936669 22412388 17435756 17554300 21102463 17447842 22293688 32581322 23850713 17804789) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28008999 18758464 28067908 23128233) Inflammatory skin disease ( 25574825) Leprosy ( 25642632 22019778) Pediatric autoimmune diseases ( 26301688) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Psoriasis ( 25903422 20953190 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Sarcoidosis ( 32826979 26051272) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 19915572 28067908 26398853 20228799 21297633 19122664 32072174) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		16 interacting genes: APP GSC2 IL23R MOGS NCOR1 NCOR2 NR1D1 PCBD2 PRKDC SASH1 SH3GLB1 SUOX THRA THRB TSNAX ZGPAT	5 interacting genes: C1D IL12RB1 IL23A JAK2 STAT3
Entrez ID		10438	149233
HPRD ID		07382	16249
Ensembl ID		ENSG00000197223	ENSG00000162594
Uniprot IDs		Q13901	Q5VWK5
PDB IDs			5MZV 6WDQ
Enriched GO Terms of Interacting Partners?
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