PIAS3 and FOXP2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		PIAS3	FOXP2
Description		protein inhibitor of activated STAT 3	forkhead box P2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck Dendrite Synapse	Chromatin Nucleus
	Molecular Function	Transcription Coregulator Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding SUMO Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Hormone Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Membrane Potential TNFSF11-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Caudate Nucleus Development Putamen Development Cerebral Cortex Development Response To Testosterone Negative Regulation Of Transcription, DNA-templated Innate Vocalization Behavior
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS			Adult body size ( 32376654) Adventurousness ( 30643258) Age at first birth ( 34211149 27798627) Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder ( 30478444) Attention deficit hyperactivity disorder or cannabis use ( 30610198) Beard thickness ( 26926045) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Cannabis use disorder ( 33096046) Childhood maltreatment ( 32066696) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790) Crohn's disease ( 22936669) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Drug experimentation measurement ( 30718321) Feeling tense ( 29500382) Fish- and plant-related diet ( 32066663) Frailty index ( 34431594) Gastroesophageal reflux disease ( 31527586) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Major depressive disorder (MTAG) ( 33479212) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Multisite chronic pain ( 33830993 31194737) Neuroticism ( 29255261) Number of sexual partners ( 30643258) Pelvic organ prolapse (moderate/severe) ( 26545240) Schizophrenia, bipolar disorder or recurrent major depressive disorder ( 34099189) Self-reported risk-taking behaviour ( 30271922 30181555) Serum sulfate level ( 27412988) Sleep duration ( 27992416) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Subcortical volume (MOSTest) ( 32665545) Urate levels in obese individuals ( 25811787) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Weight ( 28552196)
Interacting Genes		56 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ESR1 ESR2 FOXP2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNIP1 SPOP SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	23 interacting genes: ARSB CAV1 CAV2 CCNC CDK3 CTBP1 CTBP2 FAM124A FOXP1 FOXP4 GPR85 ING3 LNX1 MAPK3 MAST3 PIAS3 PIN1 RPIA SDCBP SP4 TBR1 TLE5 TSACC
Entrez ID		10401	93986
HPRD ID		09068	05611
Ensembl ID		ENSG00000131788	ENSG00000128573
Uniprot IDs		B3KNI3 Q9Y6X2	B7ZLK5 O15409 Q8N6B5 Q8N6B6 X5D2H2
PDB IDs		4MVT	2A07 2AS5
Enriched GO Terms of Interacting Partners?
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