PIAS3 and GLUL

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		PIAS3	GLUL
Description		protein inhibitor of activated STAT 3	glutamate-ammonia ligase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck Dendrite Synapse	Nucleus Cytoplasm Mitochondrion Rough Endoplasmic Reticulum Cytosol Plasma Membrane Protein-containing Complex Perikaryon Myelin Sheath Axon Terminus Extracellular Exosome Glial Cell Projection
	Molecular Function	Transcription Coregulator Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding SUMO Ligase Activity	Magnesium Ion Binding Glutamate-ammonia Ligase Activity Protein Binding ATP Binding Glutamate Binding Protein-cysteine S-palmitoyltransferase Activity Manganese Ion Binding Identical Protein Binding Dynein Light Chain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Hormone Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Membrane Potential TNFSF11-mediated Signaling Pathway	Angiogenesis Glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Response To Starvation Response To Glucose Regulation Of Endothelial Cell Migration Protein Palmitoylation Ammonia Assimilation Cycle Positive Regulation Of Insulin Secretion Ribosome Biogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism
Drugs			L-Glutamine Glutamic acid
Diseases
GWAS			Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823)
Interacting Genes		56 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ESR1 ESR2 FOXP2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNIP1 SPOP SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	22 interacting genes: CASP8AP2 CRBN CYP39A1 DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 SKIL TAT UBE2I
Entrez ID		10401	2752
HPRD ID		09068	00701
Ensembl ID		ENSG00000131788	ENSG00000135821
Uniprot IDs		B3KNI3 Q9Y6X2	A8YXX4 P15104
PDB IDs		4MVT	2OJW 2QC8
Enriched GO Terms of Interacting Partners?
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