TUBB4A and KDM4B

		TUBB4A	KDM4B
Description		tubulin beta 4A class IVa	lysine demethylase 4B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Microtubule Axoneme Internode Region Of Axon Neuronal Cell Body Myelin Sheath Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding GTP Binding	Histone Demethylase Activity Histone H3-methyl-lysine-9 Demethylase Activity Metal Ion Binding Histone H3-methyl-lysine-36 Demethylase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Negative Regulation Of Microtubule Polymerization	Chromatin Remodeling Histone H3-K9 Demethylation Histone H3-K36 Demethylation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression
Drugs		Epothilone D Patupilone CYT997 ZEN-012 Artenimol
Diseases
GWAS		Left-handedness ( 32989287) Leftâ€“right brain asymmetry ( 33723403)	Granulocyte percentage of myeloid white cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontitis (CDC/AAP) ( 24024966) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Urate levels ( 31578528) Walking pace ( 33128006)
Interacting Genes		18 interacting genes: ABCA7 APC2 BMPR2 CLN8 HMG20B KDM4B LINC01554 NEAT1 NR4A1 OGT PLIN3 SBNO2 SELENOF STAU1 STK11 SUMO2 UQCR11 YWHAG	3 interacting genes: H3-5 MED10 TUBB4A
Entrez ID		10382	23030
HPRD ID		04045	11056
Ensembl ID		ENSG00000104833	ENSG00000127663
Uniprot IDs		P04350	A0A0C4DFL8 F5GX28 O94953
PDB IDs			4LXL 4UC4
Enriched GO Terms of Interacting Partners?
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