KDM4B and H3-5

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		KDM4B	H3-5
Description		lysine demethylase 4B	H3.5 histone
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleosome Euchromatin Barr Body Nucleus
	Molecular Function	Histone Demethylase Activity Histone H3-methyl-lysine-9 Demethylase Activity Metal Ion Binding Histone H3-methyl-lysine-36 Demethylase Activity	Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Remodeling Histone H3-K9 Demethylation Histone H3-K36 Demethylation	Osteoblast Differentiation Nucleus Organization Spermatid Development Single Fertilization Embryo Implantation Cell Population Proliferation Male Gonad Development Positive Regulation Of Cell Growth Pericentric Heterochromatin Assembly Subtelomeric Heterochromatin Assembly Multicellular Organism Growth Muscle Cell Differentiation Oogenesis Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation
Pathways		HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Hip circumference adjusted for BMI ( 34021172) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontitis (CDC/AAP) ( 24024966) Pulse pressure ( 30578418) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Triglyceride levels ( 32203549) Urate levels ( 31578528) Walking pace ( 33128006)
Interacting Genes		3 interacting genes: H3-5 MED10 TUBB4A	15 interacting genes: DAXX DNAJC9 FBLIM1 KAT6A KDM1A KDM4B NASP NSD3 PRMT5 PRMT6 PRMT7 SETMAR SMYD1 SMYD3 SUV39H1
Entrez ID		23030	440093
HPRD ID		11056	18443
Ensembl ID		ENSG00000127663	ENSG00000188375
Uniprot IDs		A0A0C4DFL8 F5GX28 O94953	Q6NXT2
PDB IDs		4LXL 4UC4	2PUY 3KV4 4Z5T 5BWN 5BWO 5F6K 5I3L 6OI3
Enriched GO Terms of Interacting Partners?
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