RAMP2 and CALCRL

Number of citations of the paper that reports this interaction (PubMedID 9620797)
445

Data Source:
HPRD (in vitro)

		RAMP2	CALCRL
Description		receptor activity modifying protein 2	calcitonin receptor like receptor
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Cell Surface Receptor Complex Amylin Receptor Complex 2 Adrenomedullin Receptor Complex	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex
	Molecular Function	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Adrenomedullin Binding	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Adrenomedullin Binding
	Biological Process	Angiogenesis Vasculogenesis Response To Hypoxia Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Female Pregnancy Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Positive Regulation Of Protein Binding Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Associated Smooth Muscle Cell Development Amylin Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis	Angiogenesis Calcium Ion Transport Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Protein Transport Receptor Internalization Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Pramlintide	Olcegepant Telcagepant Rimegepant Erenumab Ubrogepant Vazegepant
Diseases
GWAS		Body shape index ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Aspartate aminotransferase levels ( 33547301) Body mass index ( 25673413) Body shape index ( 34021172) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Periventricular white matter hyperintensities ( 32517579) Resting heart rate ( 27798624) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		7 interacting genes: CALCA CALCRL CIDEB IAPP LCN2 SLC31A2 VIPR1	6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Entrez ID		10266	10203
HPRD ID		05516	11809
Ensembl ID		ENSG00000131477	ENSG00000064989
Uniprot IDs		A0A024R1Z2 O60895	D3DPG9 Q16602
PDB IDs		2XVT 3AQE 3AQF 4RWF 6UUN 6V2E	3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y 6UMG 6UUN 6UUS 6UVA 6V2E 6ZHO 6ZIS 7KNT 7KNU
Enriched GO Terms of Interacting Partners?
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