CALCRL and ADM

Number of citations of the paper that reports this interaction (PubMedID 9620797)
445

Data Source:
HPRD (in vitro, in vivo)

		CALCRL	ADM
Description		calcitonin receptor like receptor	adrenomedullin
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Adrenomedullin Binding	Signaling Receptor Binding Hormone Activity Adrenomedullin Receptor Binding
	Biological Process	Angiogenesis Calcium Ion Transport Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Protein Transport Receptor Internalization Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway	Vasculogenesis Response To Hypoxia Neural Tube Closure Regulation Of The Force Of Heart Contraction G Protein-coupled Receptor Internalization Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Aging Androgen Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Cold Response To Wounding Positive Regulation Of Heart Rate CAMP-mediated Signaling Animal Organ Regeneration Neuron Projection Regeneration Receptor Internalization Response To Lipopolysaccharide Response To Insulin Regulation Of Urine Volume Odontogenesis Of Dentin-containing Tooth Response To Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Hormone Secretion Developmental Growth Response To Glucocorticoid Branching Involved In Labyrinthine Layer Morphogenesis Vascular Associated Smooth Muscle Cell Development Amylin Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Positive Regulation Of Progesterone Biosynthetic Process Positive Regulation Of Vasculogenesis
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Olcegepant Telcagepant Rimegepant Erenumab Ubrogepant Vazegepant
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Body mass index ( 25673413) Body shape index ( 34021172) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Periventricular white matter hyperintensities ( 32517579) Resting heart rate ( 27798624) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Birth weight ( 31043758) Blood pressure ( 21909110) Blood protein levels in cardiovascular risk ( 28369058) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 27841878 21909115 27618452) HDL cholesterol ( 20686565) Neuroticism ( 27089181) Pulse pressure ( 27841878) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 27841878 21909115 27618452) Total cholesterol levels ( 33339817)
Interacting Genes		6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3	4 interacting genes: CALCRL CFH EDN1 MME
Entrez ID		10203	133
HPRD ID		11809	00061
Ensembl ID		ENSG00000064989	ENSG00000148926
Uniprot IDs		D3DPG9 Q16602	P35318
PDB IDs		3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y 6UMG 6UUN 6UUS 6UVA 6V2E 6ZHO 6ZIS 7KNT 7KNU	2FLY 2L7S 4RWF 5V6Y 6UUN 6UUS 6V2E
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?