STAM2 and EPS15

Number of citations of the paper that reports this interaction (PubMedID 12551915)
113

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		STAM2	EPS15
Description		signal transducing adaptor molecule 2	epidermal growth factor receptor pathway substrate 15
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Endocytic Vesicle Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Membrane Aggresome Apical Plasma Membrane Clathrin Coat Of Coated Pit Early Endosome Membrane Intracellular Membrane-bounded Organelle Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Phosphatidylinositol Binding Ubiquitin Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Modification-dependent Protein Binding Cadherin Binding
	Biological Process	Signal Transduction Protein Transport Macroautophagy Multivesicular Body Assembly	Positive Regulation Of Receptor Recycling Golgi To Endosome Transport Endocytosis Protein Transport Vesicle Organization Endosomal Transport Receptor-mediated Endocytosis Of Virus By Host Cell Endocytic Recycling Regulation Of Cell Population Proliferation Viral Entry Into Host Cell Clathrin Coat Assembly Postsynaptic Neurotransmitter Receptor Internalization
Pathways		EGFR downregulation Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell RHOU GTPase cycle Endosomal Sorting Complex Required For Transport (ESCRT)	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Metabolic syndrome ( 31170924) Pulse pressure ( 30224653)	Blood urea nitrogen levels ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) IgE grass sensitization ( 22036096) PR interval ( 30046033 32439900)
Interacting Genes		38 interacting genes: ABI2 ARRDC3 ATXN1 CBX5 CDC7 DAZAP2 EGFR EPS15 FAM189A2 HGS ITCH JAK1 JAK2 JAK3 KLHL42 L3MBTL2 LCP2 LITAF MAP3K1 PHF10 PLEKHB2 PTPN1 RNF11 SH2D4A STAMBP TIMM8A TYK2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBQLN1 UBQLN4 USP8 VPS37C XRN1 ZC3H10	50 interacting genes: AGFG1 AGFG2 AP1G1 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 FCHO1 FCHO2 GRB2 HGS ITSN1 LAPTM5 MAPK14 MOB4 MTNR1A NAGPA NEDD4 NUMB NUMBL PPT1 PRKN REPS2 RNF11 SCAMP1 SGIP1 SNAP91 SPART SPOPL STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1 USP8
Entrez ID		10254	2060
HPRD ID		05876	08968
Ensembl ID		ENSG00000115145	ENSG00000085832
Uniprot IDs		O75886	B7Z240 P42566
PDB IDs		1X2Q 1X5B 2L0T 5CRV 5IXF	1C07 1EH2 1F8H 1FF1 2IV9 2JXC 4RH5 4RH9 4RHG 4S0G 5AWT 5AWU 5JP2
Enriched GO Terms of Interacting Partners?
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