DCAF7 and TLK2

		DCAF7	TLK2
Description		DDB1 and CUL4 associated factor 7	tousled like kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Matrix Nuclear Body Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Ubiquitination	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation
Drugs			Fostamatinib
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lifespan ( 25918517) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		17 interacting genes: ACE AIFM1 APP ATP13A2 ATP5PD BMPR1B CBX1 DYRK1B LIG1 PCTP PWP2 SPDYA TANC2 TK1 TLK2 YWHAB YWHAG	19 interacting genes: ASF1A ASF1B AURKA CEP70 DCAF7 DMAP1 DOCK1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ
Entrez ID		10238	11011
HPRD ID		09340	10527
Ensembl ID		ENSG00000136485	ENSG00000146872
Uniprot IDs		P61962	B4DUC2 J3QLK5 Q86UE8
PDB IDs			5O0Y
Enriched GO Terms of Interacting Partners?
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