HSD17B4 and CASP9

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		HSD17B4	CASP9
Description		hydroxysteroid 17-beta dehydrogenase 4	caspase 9
Image
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane	Nucleus Cytoplasm Mitochondrion Cytosol Protein-containing Complex Apoptosome
	Molecular Function	3-hydroxyacyl-CoA Dehydrogenase Activity Enoyl-CoA Hydratase Activity Long-chain-enoyl-CoA Hydratase Activity Isomerase Activity 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA Hydratase Activity Protein Homodimerization Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Osteoblast Differentiation Fatty Acid Beta-oxidation Androgen Metabolic Process Estrogen Metabolic Process Very Long-chain Fatty-acyl-CoA Metabolic Process Medium-chain Fatty-acyl-CoA Metabolic Process Sertoli Cell Development	Kidney Development Response To Ischemia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Antibiotic Cellular Response To Dexamethasone Stimulus Leukocyte Apoptotic Process Execution Phase Of Apoptosis Regulation Of Response To DNA Damage Stimulus
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs		NADH (R)-3-hydroxydecanoyl-CoA	Pamidronic acid
Diseases
GWAS		Asthma ( 31959851) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) JT interval (sulfonylurea treatment interaction) ( 27958378) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) QT interval (sulfonylurea treatment interaction) ( 27958378) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Waist-hip index ( 34021172) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		8 interacting genes: ACTB BAK1 CASP9 CDK7 FER MAPK8 NDRG1 SNCA	48 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SLIT3 SRF VIM XIAP
Entrez ID		3295	842
HPRD ID		03514	03756
Ensembl ID		ENSG00000133835	ENSG00000132906
Uniprot IDs		A0A0S2Z4J1 B2R659 B3KSP2 P51659	F8VVS7 P55211
PDB IDs		1IKT 1S9C 1ZBQ 6Z1W 6Z1X	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?
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