WASF2 and BAIAP2

Number of citations of the paper that reports this interaction (PubMedID 11130076)
156

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		WASF2	BAIAP2
Description		WASP family member 2	BAR/IMD domain containing adaptor protein 2
Image
GO Annotations	Cellular Component	Ruffle Early Endosome Cytosol Cell-cell Junction Actin Cytoskeleton Basolateral Plasma Membrane Lamellipodium SCAR Complex Protein-containing Complex Synapse Extracellular Exosome	Ruffle Nucleoplasm Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Plasma Membrane Adherens Junction Actin Cytoskeleton Lamellipodium Secretory Granule Filopodium Neuronal Cell Body Dendritic Shaft Neuron Projection Terminus Excitatory Synapse Neuron Projection Branch Point Dendritic Spine Cytoplasm Extracellular Exosome Synaptic Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase A Regulatory Subunit Binding Cadherin Binding Protein Kinase A Binding Arp2/3 Complex Binding	Transcription Coregulator Binding Protein Binding Protein C-terminus Binding Cytoskeletal Anchor Activity PDZ Domain Binding Identical Protein Binding Proline-rich Region Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Angiogenesis Ameboidal-type Cell Migration Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Plasma Membrane Organization Axonogenesis Brain Development Insulin Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Dendrite Development Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Protein Localization To Synapse Regulation Of Synaptic Plasticity Actin Filament Bundle Assembly Actin Crosslink Formation Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cell-cell Adhesion Modification Of Synaptic Structure, Modulating Synaptic Transmission Cellular Response To L-glutamate Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Systolic blood pressure ( 30578418)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		23 interacting genes: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1	41 interacting genes: ADGRB1 APP ATN1 BAIAP2L1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 OGT PAK1 PBX2 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SHANK3 SRPK2 TBX5 TP53BP2 WASF1 WASF2 YWHAG
Entrez ID		10163	10458
HPRD ID		05796	05686
Ensembl ID		ENSG00000158195	ENSG00000175866
Uniprot IDs		Q9Y6W5	I3L4C2 Q9UQB8
PDB IDs		2A40	1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI
Enriched GO Terms of Interacting Partners?
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