WASF2 and ACTR3

Number of citations of the paper that reports this interaction (PubMedID 9889097)
281

Data Source:
HPRD (in vivo, in vitro)

		WASF2	ACTR3
Description		WASP family member 2	actin related protein 3
Image
GO Annotations	Cellular Component	Ruffle Early Endosome Cytosol Cell-cell Junction Actin Cytoskeleton Basolateral Plasma Membrane Lamellipodium SCAR Complex Protein-containing Complex Synapse Extracellular Exosome	Nucleus Cytoplasm Cytosol Arp2/3 Protein Complex Brush Border Cell-cell Junction Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Site Of Double-strand Break Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase A Regulatory Subunit Binding Cadherin Binding Protein Kinase A Binding Arp2/3 Complex Binding	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Angiogenesis Ameboidal-type Cell Migration Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Establishment Or Maintenance Of Cell Polarity Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Transcription By RNA Polymerase II Spindle Localization Cilium Assembly Actin Polymerization-dependent Cell Motility Cellular Response To Interferon-gamma
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Systolic blood pressure ( 30578418)	Alanine aminotransferase levels ( 33547301) Body shape index ( 34021172) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Systolic blood pressure in sickle cell anemia ( 24058526) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		23 interacting genes: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1	19 interacting genes: ACTR2 ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CTTN ERCC6 HCLS1 JUND LINC01554 OGT SHARPIN UBE3A WASF2 WASF3 WASL ZMYND10
Entrez ID		10163	10096
HPRD ID		05796	05024
Ensembl ID		ENSG00000158195	ENSG00000115091
Uniprot IDs		Q9Y6W5	A0A024RAI1 B4DXW1 P61158
PDB IDs		2A40	6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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