COX17 and PPBP

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COX17	PPBP
Description		cytochrome c oxidase copper chaperone COX17	pro-platelet basic protein
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Intermembrane Space	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Tertiary Granule Lumen
	Molecular Function	Copper Ion Binding Protein Binding Copper Chaperone Activity Cuprous Ion Binding	Glucose Transmembrane Transporter Activity Protein Binding Chemokine Activity Growth Factor Activity CXCR Chemokine Receptor Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Copper Ion Transport Brain Development Heart Development Positive Regulation Of Cell Population Proliferation Mitochondrial Cytochrome C Oxidase Assembly Positive Regulation Of Cytochrome-c Oxidase Activity	Inflammatory Response Neutrophil Chemotaxis Defense Response To Bacterium Positive Regulation Of Cell Division Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Glucose Transmembrane Transport
Pathways		Mitochondrial protein import	Platelet degranulation Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs			Ethanesulfonic acid Copper
Diseases
GWAS		Tau burden ( 33426524)	Metabolite levels ( 22916037)
Interacting Genes		12 interacting genes: COPS6 EEF1A1 ERG28 HADHB KATNAL1 KRTAP10-8 LRIF1 PPBP RB1 RBM48 TP53 UNC119	32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID		10063	5473
HPRD ID		05314	07171
Ensembl ID		ENSG00000138495	ENSG00000163736
Uniprot IDs		Q14061	P02775
PDB IDs		2L0Y 2LGQ 2RN9 2RNB	1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?
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